What is NAD+ (NAD and NMN)?


What is NAD+ (NAD and NMN)?

NAD+ & NMN are the biggest breakthroughs in Anti-Aging & Optimum Health.

Scientists are beginning to understand how Nicotinamide Adenine Dinucleotide (NAD+) & its cousin, Nicotinamide Mononucleotide (NMN) are able to help reverse age & Enhance Lifespan. They are both Vitamin B3 Metabolites that are found naturally in the body. As we age, levels of NAD+ decrease significantly with estimations that our levels drop by 50% in our 40s and to just 1% by the time we’re 80.

This is one of the reasons many leading researchers such as David Sinclair are focusing on effects of increasing NAD+ levels in the body through supplementation. Many of us are always in awe as to how children have so much energy all the time and it has been hypothesized that the levels of NAD+ in their bodies are higher.

Studies have shown in mice that supplementing with NAD+ enabled the mice to restore their youthful levels once again.

The main difference between NAD+ & NMN is the molecule size with NAD+ being a larger molecule than NMN; this is why many people experience a better effect from NMN as it may have a higher bioavailability than NAD+.

Why You Need NAD+ & NMN

As we age, our levels of NAD significantly drop to almost non-existent levels.

NAD transports energy in our cells and powers our mitochondria (the batteries of our cells), and is called coenzyme 1, as it powers many essential chemical reactions.

Mitochondria turns our food into energy (ATP) and with modern life stressors negatively impacting our mitochondria, it is important that we optimize the mitochondria in our bodies.

NAD+ is in all our healthy cells and low levels have been associated with poor health & age related pathologies.

Signs of low NAD+ levels low:

  • Low Strength, Stamina & Libido
  • Tiredness, Fatigue & Low-Energy
  • Weight Issues, Constant Hunger
  • Brain Fog, Concentration Problems & Poor Memory
  • Poor Skin Quality

Studies showed the mice treated with NMN had the energy & strength of young mice with levels of NAD+ raised & significant mitochondria protection.

NAD & NMN are also crucial for producing ATP via the Krebs Energy Cycle with lower NAD & NMN correlating with less energy available.

Cognitive Benefits:

  • Reduce brain fog
  • Acts as a neuro-protectant
  • Improve memory acquisition
  • Less “groggy” in the morning
  • Improved concentration + Focus

Physical Benefits:

  • Improved libido
  • Repair your DNA
  • Boost metabolism
  • Induce natural healing
  • Additional energy to enjoy life more

Studies have shown mice supplemented with NAD+ experienced a:

  • Increase in hair growth
  • 60% increase in speed on a treadmill
  • Double the increase in endurance & strength
  • Restore Stem Cells & Mitochondrial Function

Sublingual NAD+ / NMN vs. Capsule NAD+ & NMN

Sublingual - Stop The Thyroid Madness

Sublingual is a route of administration wherein a supplement is delivered under the tongue.

Unlike capsule or pill form, taking NAD+ / NMN sublingually avoids the bioavailability from decreasing drastically and it is more easily absorbed into the capillaries directly into the bloodstream.

Both NAD+ & NMN capsules have very low bioavailability, as they get degraded in the digestive tract.

When you take sublingual NAD+ & NMN, it is able to bypass the liver & stomach.

There has been evidence to show that a small quantity of NMN does reach the bloodstream via a protein transporter in the small intestine.

Despite evidence to the contrary, NMN doesn’t always have to be converted back to NR to turn into NAD.

Studies show that NMN enters our cells via the newly discovered Slc12a8 pathway confirming that NMN does not to be converted to NR.

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[1] mrc-mbu.cam.ac.uk/what-are-mitochondria
[2] science.sciencemag.org/content/350/6265/1208
[3] en.wikipedia.org/wiki/Nicotinamide_adenine_dinucleotide
[4] neurohacker.com/nad-introduction-to-an-important-healthspan-molecule
[5] leafscience.org/nmn-crosses-cell-membrane/
[7] wikipedia.org/wiki/Cellular_respiration#cite_note-1
[8] khanacademy.org/science/biology/cellular-respiration-and-fermentation/glycolysis/a/glycolysis
[9] khanacademy.org/science/biology/cellular-respiration-and-fermentation/pyruvate-oxidation-and-the-citric-acid-cycle/a/the-citric-acid-cycle?modal=1
[10] ncbi.nlm.nih.gov/books/NBK21208/