HEADS UP: Nicotine is not risk-free. Moderation and discipline required. Potentially addictive, cancerous, etc. DYOR
(Nearly) Every study on Nicotine has to be thrown in the garbage. Why? With nicotine spray, people are able to use Nicotine in a much healthier way – and many are even using it as a biohack.
To answer that previous question, let’s start with a definition. Research bias, also called experimenter bias, is a process where the scientists performing the research influence the results, in order to portray a certain outcome.  While sometimes this is unintentional, it does definitely happen.
Is it possible that nicotine could have been influenced by cigarette smoking? Likely.
Did big tobacco do a lot of harm to society? Undoubtedly.
Does that mean nicotine is a bad thing? Not necessarily.
Cigarettes have a ton of additives, not to mention the pesticides when growing tobacco… and we all know what “tar” is, right?
But what if you could remove the tar and the smoking all together? Would nicotine still be “so bad” ?
Simply put, no. Nicotine is still potentially addictive, but thanks to Nicorette nicotine sprays (links below), you can dose nicotine at 1/10th to 1/20th of what is in one cigarette (1 mg vs. 10-20 mg in a cigarette). When you can “microdose” at such a low level, is it still “as addictive” ? No, it is not as addictive – if at all. I personally, have never felt a need to “take a spray”. Frankly, the taste is enough to keep me away from abusing.
Lets look at the pros and cons of using nicotine as a biohack.
|Increased Coordination  ||Potentially Addictive (for some)|
|Increased Vigilance (watch for possible danger or difficulties)  ||Bad Taste (for some)|
|Increased Memory   ||Potentially cancerous|
|Increased Reaction Time  |
|Decreased Appetite (could be con for some)  |
Interested in buying some nicotine and trying it out? If so, I’ve included a link below.
These two orders, both containing (3) 2 packs (6 sprays) net cost was about $16 for each individual spray. Please be wary of sellers who gouge excessively – there are a lot of prices all over the place. I recommend eBay or Amazon, though it appears most shipments to USA on Amazon have been pulled. I think you may be able to pick these up from your local department store or pharmacy, like Walgreens or CVS.
One current seller I found that looks fair at $18/ea: https://www.ebay.com/itm/Nicorette-Quickmist-Duo-Mouthspray-Freshmint-2-x-150-Spray/152211636374?epid=12026640620&hash=item2370854096:g:Y7IAAOSwM2dd5KmT [no ref]
Dave Asprey of Bulletproof also put together a nice list of “best” to “worst” methods on dosing Nicotine.  You will notice he puts the mouth spray as one of the safest and best methods to take nicotine.
- Chewing tobacco
- Vaping, e-cigarettes
- Nicotine gum
- Nicotine patches
- Nicotine inhaler
- Nicotine lozenges
- Nicotine mouth spray
Further reading: https://www.health.harvard.edu/newsletter_article/Nicotine_It_may_have_a_good_side https://www.limitlessmindset.com/nootropic-ingredients/307-nicotine https://selfhacked.com/blog/28-proven-health-benefits-nicotine-4-potential-risks/ https://forum.biohack.me/index.php?p=/discussion/1364/nicotine-for-cognitive-enhancement https://medium.com/@jonathanroseland/nicotine-addictive-drug-4fa620f79eb5 https://www.linkedin.com/pulse/biohacking-my-experiments-nicotine-dmitri-lihhatsov
Sources:  https://explorable.com/research-bias  http://www.ncbi.nlm.nih.gov/pubmed/14668975  http://www.ncbi.nlm.nih.gov/pubmed/3786334  http://link.springer.com/article/10.1007/s002130050857%23page-1  http://ntr.oxfordjournals.org/content/4/2/185.abstract  http://www.ncbi.nlm.nih.gov/pubmed/9888618  http://www.ncbi.nlm.nih.gov/pubmed/12858319  http://www.ncbi.nlm.nih.gov/pubmed/15639169  https://www.gwern.net/docs/nicotine/1996-fou...  http://onlinelibrary.wiley.com/store/10.1002...  http://onlinelibrary.wiley.com/doi/10.1111/j…  https://blog.daveasprey.com/is-nicotine-the-next-big-smart-drug/